High Blood Sugar: Yamaimo (Japanese yam) (Fig. 1) >> slow down absorption of sugar by wrapping it around
High Blood Pressure: Lemon >> antioxidant effect of polyphenol
Dementia: Seaweed laver (Fig. 2) >> rich in folic acid >> toast with seaweed laver and cheese containing short-chain fatty acid which is also good for dementia, Seaweed baked with butter
Smoothening blood: Bonito flakes (Fig. 3) >> EPA and DHA prevent blood clots>> be careful in winter because don’t drink water very much >> more effective if eat with soy products like miso, tofu
Immune system: Scallion (Fig. 4) >> Null which strengthen immune cells which are macrophages, IgA and natural killer cells >> green part of scallion, more in thick scallion >> prevent a cold and flu
Aging of blood vessels (Hardening of the artery): Sesame >> vitamin E prevents oxidization of blood vessel and Sesamin lowers LDL cholesterol >> any kinds, 1 tablespoon per day is effective >> grated is better to absorb
Cold intolerance: Japanese pepper (Sansho) (Fig. 5) >> sprinkle on fried food or miso soup, mixed with mayonnaise as a dip
Osteoporosis: Yuzu (a citrus fruit) (Fig. 6) >> citric acid increases the absorption of calcium by 20 % >> use instead of vinegar >> taking the skin containing Beta-cryptoxanthin helping form bones is effective
Is it possible to recover fully from dementia?
There is neither medicine or treatment to recover fully from dementia. But there is a adhesive skin patch which is able to delay the symptoms of dementia. This patch increases acetylcholine, which is a substance transferring the information of nerves, in the brain.
Let’s check the risk of dementia
If there are more than 4 clauses applied to you, you need to be careful of dementia.
(1) What are 4 things drawn in Fig. 1?
The answer is a wine glass, a pencil, a folk and a bucket.
Dementia weakens the spatial ability, causing unable to distinguish these things and recall the name of them.
(2) Which is the same graphic as the above graphic within graphics (1) to (3) in Fig. 2?
Dementia weakens the ability to recognize 3-dimentional objects.
Food to prevent dementia
A canned mackerel in brine (Fig. 3) is effective because DHA and EPA contained in blue back fishes protect nerve cells in the brain, leading to the prevention of dementia. A canned mackerel contains DHA and EPA without losing them. Eating a can once every 1 or 2 days is effective.
A piece of Camembert cheese a day or 2 glasses of red wine are also effective (Fig. 4).
Simple exercise to prevent dementia
(1) Make your left hand scissors and right hand rock, put your right hand on your left hand and make a snail (Fig. 5 & 6).
(2) Make your left hand a rock and right hand scissors and put your left hand on your right hand (Fig. 7).
(3) Repeat (1) and (2) rhythmically.
If you can repeat this 10 times in a row, you are okay. If you can’t, please train it.
Dementia has little objective symptom so that it is important that their family or people around notice their symptoms.
(1) Having stopped watching favorite TV dramas recently.
Dementia makes difficult to follow the story of dramas like how many characters there are, the relationship between the characters. Dementia also declines the track of the day of a week, so people with dementia have come not to know what day of the week the TV program is on.
(2) Often taking a nap for more than 30 minutes
Taking a nap for more than 30 minutes is counted as that you have had deep sleep once. This has a harmful influence to the sleep at night and make it difficult to remove the substance causing dementia, which is stains in the brain.
So taking a nap for more than 30 minutes makes the risk of dementia development more than double.
But taking a nap for about 15 minutes lowers the risk of dementia development by one fifth, compared to taking no nap.
(3) Sometimes rotting the food in the refrigerator.
It has drawn an attention lately that at the beginning stage of dementia, the sense of smell is decreased.
It was known that there were three types of dementia:
(1) Alzheimer's disease caused by the deposition of amyloid-Beta.
(2) Vascular dementia caused by the blockage of brain blood vessels.
(3) Dementia with Lewy Bodies by the deposition of lewy bodies.
But there is another type of dementia, which is Dementia caused by low blood sugar.
Our brain works mainly using sugar as a source of energy, so decreasing the supply of sugar to the brain causes a dramatic fall in cognitive recognition. As a result of that, symptoms of dementia like forgetfulness, difficulty to control emotion appear. The symptoms tend to appear before meals that are the time of low blood sugar.
This low blood sugar is caused by the abnormality of the hormone which controls blood sugar so that this type of dementia can be cured by elevating blood sugar by taking medication to elevate blood sugar.
According to a study of University of Central Lancashire, when the brains of 10 people who had had Alzheimer’s disease before their death were dissected, a common toxin was discovered from the brains of 4 people.
The toxin is LPS.
LPS exist in everybody’s body, but when LPS increases by some reason, inflammation in brain cells or others occurs and the dead brain cells cause dementia.
What is the characteristic which increases LPS and heightens the risk of dementia development?
People whose LPS has increased emit a distinctive smell from a part of the body.
That is halitosis (breath).
People whose LPS has increased emit a distinctive gas from the mouth especially when they wake up in the morning.
The distinctive smell is a putrid odor like garbage which is the odor of the gas generated when LPS has increased.
The number of normal bacteria in the mouth of a healthy person is about 200 billion and if the mouth is not cared, the number is more than one trillion. Some of the bad bacteria such as periodontal disease bacteria emit LPS.
What repels LPS?
According to a study published in Spain, when honey extract was poured into the cells inflamed by the gas generated by LPS, the inflammation was suppressed by 50 %.
The substance which is contained in honey and repels LPS is flavonoid. Flavonoid is mainly contained in plants and has strong antibacterial activity to repel virus and bacteria. There are 4000 kinds of flavonoid such as isoflavone contained in soy, catechin contained in green tea, anthocyanin contained in blueberry.
By the latest study, it has turned out that 10 and several kinds of flavonoids contained in honey are especially effective to repel LPS.
Flavonoid contained in honey lowers the activity of LPS and restores the cells suppressing the inflammation when going into the body.
However, so far the effect of flavonoid contained in honey on human has not been proved yet.
A 78 years old woman whose halitosis was strong (958 (guideline: 26)) and LPS in the blood was 0.004 EU/ml attended the verification. She was feeling that her forgetfulness had been worse lately.
She did 2things for 5 days in this experiment.
(1) Take a tablespoon of honey at night
LPS increases during sleep, so it is effective to take honey at night and a tablespoon of honey is appropriate amount because honey is rich in sugar.
(2) Brushing her teeth right after every meal to remove bad bacteria in the mouth
After 5 days trial of the above 2 things, her halitosis became 233 from 958 and LPS in the blood became 0.003 EU/ml from 0.004 EU/ml. Her memory was also improved in a test.
It is necessary to continue this for a long period of time to see more improvement.
According to a study to compare the risk of the development of Alzheimer’s disease between people in India who use a lot of spices in their meals and people in USA who don’t use spices very much in their meals, people in India had one-fourth the development risk of Alzheimer’s disease of people in USA.
What is the difference between India and USA?
People in India eat curry a lot.
Turmeric used to color curry is expected to prevent dementia.
Turmeric is rich in Curcumin that is good for the brain function.
Curcumin prevents the substance causing dementia from accumulating in the brain.
The substance is called amyloid-Beta and the Accumulation of amyloid-Beta kills nerve cells.
Fig. 1 is a brain cell of a mouse and all the black dots are amyloid-Beta.
Fig. 2 is a Brain cell of a mouse having eaten curcumin every day for 17 months. There is almost no amyloid-beta.
It has turned out that curcumin removes amyloid-Beta and prevents amyloid-Beta from accumulating.
When does amyloid-Beta start to accumulate from?
Amyloid-Beta starts to accumulate from the age of 50s and dementia is developed in their 70s-80s.
People of all ages should eat curry to prevent dementia.
If you don’t like curry so much, you can add turmeric to your soup or other dishes.
The major cause of dementia (Alzheimer’s disease) is considered as “Waste” in the brain. Accumulation of the “Waste” in the brain kills the nerve cells, causing dementia.
According to the latest research, it has turned out that dementia can be prevented by removing the “Waste” in the brain.
“Waste” in the brain exists even in the brain of young people such as 20s or 30s. The important thing is whether the power to remove the “Waste” in the brain is strong or not.
What is “Waste” in the brain?
“Waste“ in the brain is protein deposit called amyloid beta-protein (Fig. 1). It is unknown why the accumulation of the “Waste” occurs.
According the latest research, it is okay if Amyloid beta-protein can be removed even if they are created in the brain.
Amyloid beta is produced in everybody’s brain. The important thing is whether the strength to remove amyloid beta becomes weak or not.
The amount of “Waste” in the brain (amyloid beta) of the person who have dementia due to the weakness of the removal strength is 25 times more than the one of a normal person with the same age.
What makes the difference of the power to remove the “Waste”?
One of the major causes that makes the power to remove amyloid beta worse is related to the movement of a part of the body.
18 and 20 years old women attended an experiment.
Amyloid beta is produced in everybody’s brain regardless of the age.
If the power to remove amyloid beta is strong, amyloid beta is excreted into the blood, so it doesn’t affect the brain function. If the power to remove amyloid beta becomes weak, the amount of amyloid beta in the blood decreases.
The amounts of their amyloid beta in the blood are 6.82 and 5.87 (pmol/L) before the experiment.
After they spent 10 hours in a comfortable room watching movies, taking a nap, eating anything they liked to eat, the amounts of their amyloid beta in the blood decreased from 6.82 to 1.05 and from 5.87 to 0.74 (pmol/L). That means that their brain became unable to remove amyloid beta.
The movement of what part of the body became worse?
That is the pulsation of the blood vessel.
What is the relationship between the pulsation of the blood vessel and the power to remove amyloid beta?
Amyloid beta is produced in the cell and accumulated in the brain. If the blood vessel is pulsated properly, amyloid beta produced in the brain is pushed out of the brain through the blood vessel and excreted from the body.
But if the pulsation of the blood vessel becomes weak, amyloid beta stays in the brain and can’t be flowed out of the brain.
The cause of lowering the pulsation of the blood vessel is progression of hardening of blood vessels due to bad life habits.
How to strengthen the power to remove amyloid beta by heightening the pulsation of the blood vessel
Taking a nutrition heightens the pulsation of the blood vessel, strengthening the power to remove amyloid beta.
The nutrition is Resveratrol.
Resveratrol is a type of polyphenol contained in the skin of grapes and peanuts. But at this time it is unknown how much is needed and how effective taking resveratrol is.
2 women whose ages were 78 and 69 and who were worrying about their cognitive function attended an experiment.
The amounts of their amyloid beta were 1.06 and 1.89 (pmol/L) before the experiment.
They ate 10-15 peanuts with the skin a day and 10 minutes walking a day.
78 years old woman: amyloid beta in the blood became 6.89 (pmol/L) in 5 days and brain age became 50s from 80s.
69 years old woman: amyloid beta in the blood became 8.47 (pmol/L) in 2 days.
The numbers were improved in a very short time and were better than the young women who attended earlier experiment.
Based on this experiment, combination of peanuts with the skin and 10 minutes walking can be expected to improve the power to remove “Waste” in the brain and prevent dementia.
The amount of vitamin D in the body is proportionate to cognitive function and the strength of legs.
Function of Vitamin D
Vitamin D restores declining body cells.
We have about 60 trillion cells. The cells are damaged and decline by aging and others.
Vitamin D restores the cells and protects around the cells.
Usually nerve cells in the brain and muscle cells are not easily restored, but vitamin D is expected to be able to restore them.
How to increase Vitamin D
The amount of vitamin D in the blood expected to be effective for our health is 30 ng/ml
There are very few people whose vitamin D is more than 30 ng/mL. In a research, there are only 2 people among tested 300 people.
1 slice of salmon (100 grams) contains vitamin D of 40 shiitake mushrooms which is considered containing a lot of vitamin D.
In a town in Japan where the cultivation of salmon is popular, there were 30 time more people whose vitamin D is more than 30 ng/mL.
The efficient way to intake vitamin D from salmon is eating the skin of salmon as well.
Vitamin D is oil soluble and there is a lot of vitamin D between the skin and the flesh of salmon. The skin of salmon has more vitamin D than the flesh.
Memory gradually starts to fall from 30s.
Q1. Which waking speed makes the risk of dementia higher?
(A) Fast (B) Slow
A1. (B) Slow
If the walking speed is slow, the risk of dementia is 1.77 times higher.
The motor area in the brain orders the body to walk fast. The nerve cells in the brain transmit the information to the arms and legs and we can walk fast. But if the nerve cells die, the information can’t be transmitted to the arms and legs, resulting in being unable to walk fast.
If the walking speed is slower than 90 cm per second, there is a risk of dementia.
That is, if you can’t cross the crosswalk during the green light, there is a risk of dementia.
Even if you forget something, if you can remember, that is just forgetfulness.
But if you forget that you made a promise itself, that can be a sign of dementia.
Q2. Which steps of walking makes the risk of dementia higher?
(A) Long steps (B) Short steps
A2. (B) Short steps
Q3. Which exercise is expected to prevent dementia?
(A) Aerobic exercise such as walking (B) Anaerobic exercise such as weight training
A3. (A) Aerobic exercise such as walking
Aerobic exercise helps produce BDNF which is a kind of protein that activates the brain. BDNF is not only produced in the brain but also is produced by the contraction of the muscles and is transmitted to the brain. BDNF restores the network of the nerve cells in the brain.
MCI (Mild Cognitive Impairment) is a condition that there is a slight decline of cognitive abilities, but no difficulty in daily life. But if a person with MCI doesn’t take any countermeasure, over half of those with MCI are at a risk of developing dementia within 4 years.
Q4. Which contains the substance that is expected to prevent dementia?
(A) Blue cheese (B) Camembert cheese
A4. (B) Camembert cheese
The substances contained in camembert cheese such as Oleic amide decreases amyloid beta which causes dementia. People with Alzheimer’s disease store amyloid beta abnormally. Amyloid beta is considered that it emits toxins to kill the nerve cells.
Q5. Which contains substances that is expected to prevent dementia?
(A) Beer (B) Distilled liquor
A5. (A) Beer
Hop (iso-α acid) which is bitterness of beer is expected to decrease amyloid beta. Proper amount is 1 to 2 bottles of beer a day. Too much consumption of alcohol progresses dementia.
Red wine is rich in polyphenol which has antioxidant effects.
Q6. Which should be taken positively to reduce the risk of dementia?
(A) Rice (B) Milk
A6. (B) Milk
According to a research, people who took more vegetables, beans, sea vegetables and milk and took less rice reduced the risk of dementia by 30 %. This research suggests that eating rice is not bad but if you eat more rice, you can’t eat other things, so it is better to reduce the amount of rice (carbohydrate). To prevent dementia, it is important to take various kinds of nutrition through balanced meals.
Reading a picture book to a child activates the brain and prevents dementia.
Telling new information you have learned recently to your family has also the same effect as reading a picture book.
Q7. How long should you take a nap to reduce the risk of dementia by 80 %?
(A) 30 minutes (B) One and a half hours
A7. (A) 30 minutes
Short nap within 30 minutes is effective to prevent dementia. But nap more than 1 hour raises the risk of dementia.
Short nap within 30 minutes lowers the stress caused by lack of sleep. When you are sleepy, your brain is stressed and nerve cells in the brain can be damaged.
A human being has biological rhythms that they get sleepy 8 hours after waking up. But if you put up with sleepiness and continue what you are doing, that stress weakens the nerve cells in the brain. That is why taking a nap reduces the stress of the brain.
10 minutes nap doesn’t affect the sleep at night, but if you sleep too much during the daytime, that affects the sleep at night.
When you take a nap, the sleep should be light so you should not darken the room or change clothes but take a nap on the couch.
Recommended time of taking a nap is within 8 hours after waking up in the morning and the length is within 30 minutes.
Q8. How many hours should you sleep at night to prevent dementia?
(A) 5 hours (B) 7 hours
A8. (B) 7 hours
According to a research, between less than 6 hours, 7 hours and more than 8 hours of sleep, 7 hours sleep lowered the risk of dementia.
According to a research for 10 years in US, a game called Brain HQ reduced the risk of dementia by 48 %.
Red wine, blue-skinned fish, curry and others are famous as food to prevent dementia.
The cause of dementia is something like flecks produced in the brain with aging, which is called amyloid beta. Especially the flecks produced in the seahorse of the brain lower the function of memory, leading to dementia.
The newest research found a food which suppresses the flecks in the brain. The food effective to prevent dementia is camembert cheese. Camembert cheese contains oleic acid amid and dehydroergosterol which suppress the increase of flecks in the brain (amyloid beta) because these two substances are produced during the process of the fermentation of camembert cheese by white mold.
Eating 1 to 2 pieces of camembert cheese a day is effective to prevent dementia. Drinking 3 to 4 glasses of red wine with camembert cheese is more effective. The rate of dementia development of the people who drink 3-4 glasses of red wine a day is one fifth of the people who don’t drink.
According to the research reported the last November, the bitterness of beer is effective to prevent dementia. The bitterness effective to prevent dementia is hop origin. A can of beer a day is good amount.
This Blog is for a memo of my clinical realizations, information about health I learned recently and update information.